I am an associate professor and principal investigator at the Big Data Engineering Center, Children's Hospital of Chongqing Medical University. Previously, I was an assistant professor at Nankai University. I received my Ph.D. in Statistics from the University of Toronto in 2012, and I was fortunate to have Prof. Nancy Reid as my advisor for my thesis. After graduation I became a postdoctoral fellow at Dalhousie University (working with Prof. Chris Field). Before going to UofT, I got my bachelor's degree from Nankai University and master's degree from University of Ottawa under the supervision of Prof. David Sankoff.

At PediatriXlab (www.pediatrixlab.com), our primary focus is to address data-driven challenges in pediatrics through the integration of data analytics and artificial intelligence. The "X" in our name symbolizes both an interdisciplinary approach and a quest into the unknown.

 

(1) 国家自然科学基金委员会, 面上项目, 11871287, 不可忽略缺失数据的若干理论研究及其应用, 2019- 01-01 至 2022-12-31, 52万元, 在研, 参与 ；

(2) 国家自然科学基金委员会, 青年科学基金项目, 11701294, 大规模微生物组数据的稳健统计推断, 201 8-01-01 至 2020-12-31, 24万元, 结题, 主持 ；

(3) 国家自然科学基金委员会, 青年科学基金项目, 11701296, 基于结构特征和机器学习的蛋白质结构模 型评估新方法研究, 2018-01-01 至 2020-12-31, 25万元, 结题, 参与；

(4) 重庆市人力资源和社会保障局, 留创计划创新类项目, cx2021112, 人体微生物组数据的动态建模与统 计分析, 2021-11 至 今, 5万元, 在研, 主持。

 

• Wei, Q., Xiao, Y., Yang, T., ..., Xu, X. , Li, T. (2024). Predicting Autism Spectrum Disorder Using Maternal Risk Factors: A Multi-Center Machine Learning Study. Psychiatry Research, 115789.

• Wei, Q., Yao, Z., Cui, Y., Wei, B., Jin, Z., Xu, X. . (2024). Evaluation of ChatGPT-generated medical responses: A systematic review and meta-analysis. Journal of Biomedical Informatics, 104620.

• Xu, L., Reid, N., Xu, X. (2023). A note on information bias and efficiency of composite likelihood. Statistica Sinica, 2023, 34: 523-526.

• Xu, L., Kong, D., Wang, L., Gu, H., Kenney, T., Xu, X. (2023). Proportional stochastic generalized Lotka-Volterra model with an application to learning microbial community structures. Applied Mathematics and Computation, 448: 127932.

• Wei, Q., Wang, Y., Yao, Z., Cui, Y., Wei, B., Li, T., Xu, X. (2023). Evaluation of ChatGPT’s performance in providing treatment recommendations for pediatric diseases. Pediatric Discovery, 1(3), e42.

• Hu, S., Xu, X. , Li, C., et al. (2023). Long-term exposure to ambient ozone at workplace is positively and non-linearly associated with incident hypertension and blood pressure: longitudinal evidence from the Beijing-Tianjin-Hebei medical examination cohort. BMC Public Health, 23: 2011.(PhD student Songhua Hu is the first author)

• Wei, Q., Cui, Y., Wei, B., Cheng, Q., Xu, X. (2023). Evaluating the performance of ChatGPT in differential diagnosis of neurodevelopmental disorders: A pediatricians-machine comparison. Psychiatry Research, 327: 115351.

• Wei, Q., Xu, XL.,  Xu, X. , Cheng, Q. (2023). Early identification of autism spectrum disorder by multi-instrument fusion: A clinically applicable machine learning approach. Psychiatry Research, 320: 115050.

• Xiao, L., Xu, X. , et al. (2023). Low total cholesterol predicts early death in children with hemophagocytic lymphohistiocytosis. Frontiers in Pediatrics, 10: 1006817.

• Wei, Q., Cao, H., Shi, Y., Xu, X. , Li, T. (2022). Machine learning based on eye-tracking data to identify Autism Spectrum Disorder: A systematic review and meta-analysis. Journal of Biomedical Informatics, 137: 104254.

• Luo, Y., Tan, L., et al. (2022). Characteristics of wild bird resistomes and dissemination of antibiotic resistance genes in interconnected bird-habitat systems revealed by similarity of bla_TEM polymorphic sequences. Environmental Science & Technology, 56 (21), 15084-15095.

• Li, J., An, X., Xu, X. , et al. (2022). Type O blood, the MCHC, and the reticulocyte count impact the early recurrence of primary warm-antibody autoimmune hemolytic anemia in children: a retrospective cohort analysis. Frontiers in Pediatrics, 10: 881064.

• Li, Y., Xu, X. , Guo, Z., et al. (2022). Neonatal Streptococcus pneumoniae infection induces long-lasting dysbiosis of the gut microbiota in a mouse model. Frontiers in Microbiology, 13: 961684.

• He, J., Hu, S., Xu, X. , et al. (2022).  Association of long-term exposure to PM2. 5 in workplace with fasting plasma glucose among asymptomatic adults: A multicenter study in North China. Environment International, 166: 107353. (PhD student Songhua Hu is the co-first author)

• Aeberhard, W., Cantoni, E., Field, C., Künsch, H., Mills-Flemming, J., and Xu, X. (2021). Robust estimation for discrete-time state space models. Scandinavian Journal of Statistics, 48，1127-1147. (Authors are alphabetically ordered)

• Ma, J., Xu, XL., Li, M., Zhang, Y.…, Xu, X. , Wang, Y. (2021). Predictive models of aging of the human eye based on ocular anterior segment morphology. Journal of Biomedical Informatics, 120: 103855. (PhD student Xueli Xu is the co-first author)

• Zeng, Q., Yang, Z., Wang, F., Li, D., .…, Xu, X. , Dai, W. (2021). Association between metabolic status and gut microbiome in obese populations. Microbial Genomics, 7：000639.

• Xu, X. and Xu, L. (2020). Existence and asymptotic behaviour of positive solutions to a stochastic multispecies Holling type II model. Stat, 9: e266.

• Xu, XL., Xie, Z., Yang, Z., Li, D. and Xu, X. (2020). A t-SNE based classification approach to compositional microbiome data. Frontiers in Genetics, 11:620143. (PhD student Xueli Xu is the first author)

• Li, H., et al. (2020). The prolonged disruption of a single-course amoxicillin on mice gut microbiota and resistome, and recovery by inulin. Environmental Pollution, 265: 114651.

• Yang, J., Li, D., Yang, Z. …, Xu, X. , et al. (2019). Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families. Gut Microbes, 11, 918-929. (PhD student Zhenyu Yang is the co-first author).

• Dong, G., Zhang, J., Yang, Z. …, Xu, X. , et al. (2019). The association of gut microbiota with idiopathic central precocious puberty in girls. Frontiers in Endocrinology, 10: 941.(PhD student Zhenyu Yang is the co-first author).

• Huang, C. …, Xu, X. , et. al. (2019). Distinct gut microbiota composition and functional category in children with cerebral palsy and epilepsy. Frontiers in Pediatrics，7: 394.

• Dai, W., et al. (2019). An integrated respiratory microbial gene catalogue to better understand the microbial aetiology of Mycoplasma pneumoniae pneumonia. GigaScience, 8: giz093.

• Zhou, P., et al. (2019). Perinatal antibiotic exposure affects the transmission between maternal and neonatal microbiota and is associated with early-onset sepsis. Msphere, 5: e00984-19.

• Li, D., et al. (2019). Intestinal Bacteroides sp. imbalance associated with the occurrence of childhood undernutrition in China. Frontiers in Microbiology, 10:2635.

• Zeng, Q., et al. (2019). Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities. Scientific Reports, 9: 13424.

• Xu, X. , Cantoni, E., Mills-Flemming, J. and Field, C. (2015). Robust state space models for estimating fish stock maturities. Canadian Journal of Statistics, 43, 133-150.

• Xu, X. , Dunn, K. and Field, C. (2015). A robust ANOVA approach to estimating a phylogeny from multiple genes. Molecular Biology and Evolution, 32, 2186-2194.

• Xu, X. and Reid, N. (2011). On the robustness of maximum composite likelihood estimate. Journal of Statistical Planning and Inference, 141, 3047-3954.